Crews will begin tearing down the home in the 3000 block of South 48th Court early Friday morning and it should be completely gone by the end of the weekend, said Cicero spokesman Ray Hanania.
A coach house behind the home next door will not be torn down because of insurance issues that still need to be completed.
Seven people, ranging in age from 20 years to three-days-old, were killed in the fire that tore through the three-flat building. A firefighter was injured when a portion of a chimney collapsed on him.
The dead included Sallie Gist, 18; Gist's two children, Rayshawn Reed, 3, and newborn Byron Reed; her twin siblings, Elisha and Elijah Gist, 16; her boyfriend, Byron Reed, 20, and family friend Tiera Davidson, 19.
As many as 30 people may have been living in three apartments in the building at the time of the fire, authorities said.
The landlord, Lawrence Meyers, and property manager, Marion Andre Comier, have been charged with arson and murder. Prosecutors say the men were recorded on audio tapes discussing burning down the property to collect insurance money.