Pierce had nine boards and Rondo dished out six helpers for Boston, which celebrated its championship from last season before Tuesday's season-opening 90-85 home victory over LeBron James and the Cleveland Cavaliers.
The No. 1 overall draft pick this past April, Derrick Rose, led the way for Chicago with 18 points, while Tyrus Thomas and Ben Gordon dropped 11 each for the Bulls, who started their season with a 108-95 home win over the Milwaukee Bucks on Tuesday in head coach Vinny Del Negro's debut with the team.
Chicago shot a woeful 29.8 percent from the field (25-for-84)
The Celtics dominated the first half and came away with a 24-13 lead after the first quarter and eventually a 49-31 advantage at the half.
The Bulls went a stretch of almost five minutes without a bucket in the third, which played a role in the Celtics' 70-54 lead heading into the final frame.
Boston maintained complete control throughout the remainder of the contest, stretching its lead to 28 with a little over 3 1/2 minutes left in the fourth quarter.