Mack, who was one of four Bears players slated to participate in the game, withdrew because of injury, the league said. He will be replaced by Green Bay Packers linebacker Za’Darius Smith.
In 16 games with the Bears, Mack registered five forced fumbles, four defended passes, and eight and a half sacks. He also had 47 tackles, matching his total from a season ago, and 14 total quarterback hits.
Mack has been named to the Pro Bowl in each of the last five seasons, including both of his campaigns with the Bears.
Safety Eddie Jackson, cornerback Kyle Fuller and special teams specialist Cordarrelle Patterson will all still participate in the game, which will kick off at 2 p.m. Sunday.