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What kind of cancer did OJ Simpson have? What to know after his death at 76

The former football star was acquitted of the 1994 killing of his ex-wife Nicole Brown Simpson and her friend Ronald Goldman in what became known as "The Trial of the Century."

O.J. Simpson died at the age of 76, his family announced Thursday, after a battle with cancer.

Early in 2024, it was reported that Simpson, the former football star who was acquitted of killing his ex-wife and her friend in what became known as "The Trial of the Century," had been diagnosed with and was being treated for prostate cancer. 

His family announced his death on his X account, tweeting "On April 10th, our father, Orenthal James Simpson, succumbed to his battle with cancer. He was surrounded by his children and grandchildren. During this time of transition, his family asks that you please respect their wishes for privacy and grace."

What to know about prostate cancer

According to the Mayo Clinic, prostate cancer is one of the most common types of cancer.

"Many prostate cancers grow slowly and are confined to the prostate gland, where they may not cause serious harm. However, while some types of prostate cancer grow slowly and may need minimal or even no treatment, other types are aggressive and can spread quickly," the clinic's website reports.

What are the symptoms of prostate cancer?

The American Cancer Society reports symptoms of prostate cancer may not develop during early stages. Those that do might include problems urinating or blood in the urine or semen, the society states.

Symptoms are more common in advanced stages, however, including:

  • Trouble getting an erection (erectile dysfunction or ED)
  • Pain in the hips, back (spine), chest (ribs), or other areas, from cancer that has spread to the bones
  • Weakness or numbness in the legs or feet, or even loss of bladder or bowel control, from cancer in the spine pressing on the spinal cord
  • Weight loss
  • Feeling very tired

What to know about O.J. Simpson

Simpson’s journey -- from football stardom to celebrity as an actor and broadcaster, and finally to criminal notoriety — made him, in the words of one of his lawyers, one of the most famous people on the planet.

Born Orenthal James Simpson, he grew up in public housing in San Francisco’s Portrero Hill neighborhood, going on to play running back for the University of Southern California. In 1968, his senior year, he won the Heisman Trophy.

After college, Simpson was drafted in the NFL as the No. 1 pick by the Buffalo Bills. He became the first running back to gain 2,000 yards in a season in 1973 and became a Hall of Famer. He spent 11 years in the league, mostly with the Bills, and was considered to be one of the greatest running backs of all time. He retired from the NFL with the San Francisco 49ers in 1979.

He then branched out from sports into entertainment and broadcasting, acting in movies like “The Naked Gun” trilogy. He also served as a Hertz rent-a-car pitchman and a football commentator.

Then, in 1994, Simpson was accused of the double murder of his ex-wife Nicole Brown Simpson and her friend Ronald Goldman at Simpson’s home in Brentwood, California. In what became known as “The Trial of the Century,” Simpson was acquitted of the double slayings. The trial itself was a spectacle, the focus of breathless gavel-to-gavel TV coverage, with Simpson represented by a legal “Dream Team” that included the late Johnnie Cochran Jr. and F. Lee Bailey.

READ: A look back at the historic OJ Simpson chase, and his flight to Chicago the night of the killings

Three years later, however, Simpson was found liable for the deaths by a California civil court jury and ordered to pay $33.5 million to the victims’ families.

In a separate case more than a decade later, Simpson was convicted by a jury in Las Vegas and sentenced to prison for leading five men, including two with guns, in a 2007 confrontation with two sports collectibles dealers in a cramped room at an off-strip Las Vegas casino hotel.

Simpson insisted he only wanted to retrieve personal mementoes and items stolen from him following his acquittal in the double killings.

After serving nine years in a Nevada prison for the armed robbery, Simpson was granted good behavior credits and discharged from parole on Dec. 1, 2021. The then-74-year-old continued to reside in the gated Las Vegas community where he had moved after being granted parole. Simpson became a frequent poster to Twitter, now X, offering sports takes and photos from the golf course, where he spent much of his post-incarceration free time.

The Associated Press contributed to this report.

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