A.J. Pierzynski drove in his second run of the game with a sacrifice fly in the ninth inning and the Chicago White Sox hung on to beat the Colorado Rockies 3-2 on Wednesday night.
Carlos Quentin and Paul Konerko hit singles off Huston Street (0-2) to start the ninth with Quentin getting to third on Konerko's hit. Street struck out Alexei Ramirez before Pierzynski, who had an RBI double earlier, drove a fly ball to right field.
Seth Smith ran in to make the catch but his throw home bounced near the third base line and catcher Chris Iannetta's attempt to snag the ball came up empty, allowing Quentin to cross the plate with the winning run.
Sergio Santos got three outs -- two on strikeouts -- for his 16th save in 18 chances.
Colorado missed a chance to take the lead in the eighth with the game tied 2-2.
The Rockies loaded the bases with one out and reliever Brian Bruney (1-0) then induced Wigginton, whose bloop single drove in the winning run in Colorado's 3-2, 13-inning victory Tuesday night, to ground into a double play.
Chicago starter Mark Buehrle had won 10 consecutive interleague decisions and came in with a major league-leading 24 wins in interleague play. Staked to a 2-0 lead against Colorado ace Ubaldo Jimenez, he appeared to be on course toward another victory.
But Jason Giambi broke up Buehrle's shutout bid with two outs in the sixth inning, when he drove his 1-2 offering into the bleachers in left field for his ninth home run to pull the Rockies within 2-1.
Colorado evened the score on Wigginton's leadoff homer in the seventh, marking the first time this season Buehrle had given up multiple homers in a game.
One out later, Ryan Spilborghs singled and went to third when Buehrle's errant pickoff throw got past Konerko at first base. The wild pickoff throw ended a string of 51 consecutive errorless starts by Buehrle, who has won a Gold Glove in the previous two seasons.
The White Sox got to Jimenez for two runs in the fourth, taking advantage of a lapse in Jimenez's control. Jimenez walked Juan Pierre to start the inning and after retiring Brent Morel on a flyout, hit Quentin with a pitch. Konerko followed with an RBI single and Pierzynski had a run-scoring double with two outs.
Both Jimenez and Buehrle went seven innings and were not involved in the decision. Buehrle allowed seven hits and two runs with two walks and four strikeouts. Jimenez allowed two runs and four hits with two walks and four strikeouts.