The Milwaukee Brewers used a power surge to maintain their strong start and keep the Chicago Cubs reeling.
Facing off for the first time this season on Friday night, the Brewers outslugged the Cubs 13-10 in an early season showdown of teams already heading in opposite directions.
Ryan Braun and Eric Thames hit three-run homers and the Milwaukee Brewers connected five times in all to send Chicago to its sixth straight loss.
Hernan Perez, Yasmani Grandal and Orlando Arcia also homered for the defending NL Central champions, who improved to 7-1. They have won nine of their last 12 games against the Cubs, including the division tiebreaker last season.
Jose Quintana, who had dominated the Brewers over the past two seasons struggled by laboring through a 32-pitch first inning in his first start of the season.
"I think they really ambushed me tonight," Quintana said.
Quintana had a 4-1 record with a 2.13 ERA against the Brewers last season. In 11 starts against Milwaukee coming into the game, he was 6-2 with a 1.62 ERA.
"We were laying off the inside pitches that we always swing at," Perez said. "We were patient and put good swings on strikes."
Jason Heyward, Daniel Descalso and Willson Contreras homered for the Cubs, who fell to 1-6.
Milwaukee wasted no time getting to Quintana (0-1), with Christian Yelich hitting an RBI double in the first and scoring on Braun's single.
Braun homered in a four-run second, and back-to-back home runs by Perez and Grandal made it 8-0 in the third.
"We've struggled scoring against (Quintana)." Brewers manager Craig Counsell said. "I thought (hitting coach) Andy (Haines) gave the guys a really solid plan today and they followed through on it."
Quintana gave up eight earned runs, tying a career high, and eight hits and three walks.
"They weren't missing anything," Cubs manager Joe Maddon said.
Descalso hit a three-run homer off Milwaukee starter Brandon Woodruff in the fourth and Kris Bryant added an RBI double in the inning.
Chase Anderson (1-0) allowed one hit in three innings.
Arcia extended the Brewers' lead to 10-5 with a two-run homer in the fifth. Thames made it 13-5 with a pinch-hit drive in the seventh.