Gary Harris, 50, of Chicago was attempting to cross from the right shoulder of the highway when he was struck by an eastbound silver Honda, according to a state trooper.
It appears Harris was homeless and lived in a car on the other side of the expressway, said Illinois State Police District Chicago Master Sergeant Joe Stangl.
Illinois State Police-District Chicago responded to the accident at South Central Avenue at 9:53 p.m. The driver remained at the scene of the accident waiting police.
Harris was pronounced dead at Mount Sainai Hospital at 10:34 p.m., said the Cook County medical examiner's office.
The driver of the CR-V immediately stopped, Stangl said. The driver was not impaired and no citations were issued.