The Houston Astros lost 100 games in a season for the first time in franchise history, squandering a bases-loaded chance in the ninth inning and falling to Rodrigo Lopez and the Chicago Cubs 2-1 Saturday.
The Astros, who began play in 1962 as the Colt .45s, dropped to 51-100. Minnesota has the second-most losses in the majors this season with 91.
Colorado and the Angels are the only remaining franchises that have never lost 100 games in a season.
The Cubs, meanwhile, won for the 4,000th time since moving into Wrigley Field in 1915. Only the Yankees at the original Yankee Stadium and Red Sox at Fenway Park have won more games in one ballpark than the Cubs have taken at their ivy-covered home.
Lopez (6-6) didn't allow an earned run and held the Astros to four hits in six innings while striking out seven. Sean Marshall held on in the ninth for his fifth save.
Clint Barmes' one-out double put runners on second and third, then Marshall intentionally walked J.D. Martinez to load the bases. But Jose Altuve struck out and pinch-hitter Humberto Quintero grounded out to end the game.
Bryan LaHair hit a solo homer and reached base three times for the Cubs.
LaHair, who led the minor leagues with 38 homers, continued his impressive September audition with a drive to dead center field on the first pitch by Henry Sosa (2-5) in the fourth. LaHair also walked twice and is hitting .433 in 30 at-bats since his promotion.
Sosa recovered from first-inning control problems to throw six innings, holding Chicago to four hits and two runs with five walks and five strikeouts.
Sosa hadn't walked more than three batters in any of his 36 appearances, including 17 starts, between the majors and minors this season. He walked four in the first inning, leading to the Cubs' first run.
The first free pass was issued to speedy Tony Campana, who moved to second on a groundout, stole third and scored when the throw by catcher Carlos Corporan sailed into left field.
Campana also reached on an infield single in the seventh. Despite playing on a part-time basis, Campana leads the Cubs with 22 steals and has been caught only once. His 95.7 percent success rate is the best in the majors.
Lopez matched his season high with five strikeouts in just three innings. He reached his season high in the fourth and finished his most whiffs since July 22, 2010.
Jordan Schafer led off the game with a double and scored on third baseman Aramis Ramirez's throwing error, putting Houston ahead.
The Astros threatened in the eighth, but Kerry Wood struck out J.B. Shuck looking with runners on the corners to end the inning.