Jonathan Villar and Adam Jones homered, rookie Cedric Mullins had a career-high four hits and the Baltimore Orioles beat the Chicago White Sox 8-4 Sunday to avoid a three-game sweep.

Baltimore took control with a five-run first inning against Lucas Giolito (10-11) and held on for its 43rd victory. That means the Orioles can't match the major league record of 120 losses in a season, set by the 1962 New York Mets.

Daniel Palka hit two solo home runs and Yolmer Sanchez had a two-run shot for the White Sox. All three homers came off rookie David Hess, who didn't make it out of the fifth inning.

Ryan Meisinger (1-0) got the final two outs in the fifth for his first major league victory, and Paul Fry finished for his initial big league save.

The Orioles sent nine players to the plate in their biggest first inning of the year. Villar and Jones both hit RBI singles before DJ Stewart collected his first major league RBI with a grounder. Jones scored on an error, and Breyvic Valera capped the uprising with a sacrifice fly.

It was 6-1 in the fifth before home runs by Sanchez and Palka chased Hess.

Jones hit his 15th homer in the seventh. It's been a strange month for the 33-year-old veteran, who's seen a lot of bench time while the rebuilding Orioles look at a few of their younger outfielders.