xe variant

Why Chicago's Top Doctor Isn't Worried About Emerging COVID Variant XE Just Yet

The XE variant is a recombinant, meaning it has parts of two different variants rearranged into a new virus, which in this case are BA.1, the original strain of omicron, and BA.2

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A new hybrid COVID variant known as XE spreading in the United Kingdom is making plenty of headlines with concerns about its transmissibility, but Chicago's top doctor said she's not concerned about it just yet.

"Mostly, it's been detected in the UK, several hundred cases, but nothing at this point that is clearly showing major concern or spread," Chicago Department of Public Health Commissioner Dr. Allison Arwady said in a statement. "And so it hasn't even been labeled at this point, an official variant of interest."

Arwady noted that while the recombinant variant has been detected in the U.S. already, no cases have been reported in Chicago or Illinois as of Monday.

"Whenever you see a new variant emerge, the main thing is it's got... it may have some little advantage, maybe a little more contagious, but no, this is not one at this point that I have any specific concern about," she said. "It remains sort of a version of omicron."

The XE variant is a recombinant, meaning it has parts of two different variants rearranged into a new virus, which in this case are BA.1, the original strain of omicron, and BA.2, known as "stealth omicron."

It was first detected in mid-January in the United Kingdom, where more than 600 cases have been reported since, according to the UK's Health Security Agency.

According to the Chicago Department of Public Health, a handful of XE cases have been reported outside the U.K., including in the U.S.

Recombinant variants themselves are not out of the ordinary, according to health officials.

"Recombinant variants are not an unusual occurrence, particularly when there are several variants in circulation, and several have been identified over the course of the pandemic to date," Hopkins said. "As with other kinds of variant, most will die off relatively quickly."

In the U.K., health officials are monitoring two other recombinants: XD and XF, which consist of genetic material from the Delta and BA.1 strains, as well as the XE variant.

According to the Centers for Disease Control and Prevention's website, XE isn't currently being monitored by U.S. epidemiologists nor has it been labeled as a "variant of interest" or "variant of concern."

WHO said it will continue to study recombinants and provide updates as further evidence becomes available.

XE might be the fastest-spreading strain yet, according to preliminary research, but studies are underway to determine the exact contagiousness of the variant.

Early growth rates of the variant weren't significantly different from BA.2, the UK Health Security Agency initially said. However, in an update on March 25, health authorities revealed more recent data showed XE had a growth rate of 9.8% above BA.2.

The World Health Organization released similar information, citing estimates that show XE is 10% more transmissible than BA.2. However, those findings require further confirmation, the agency noted.

The more contagious omicron subvariant BA.2 has become the dominant COVID-19 strain in the U.S., but international health experts are putting an increased focus on a new hybrid variant that may even be more infectious.

BA.2 was previously identified as the most transmissible variant as it spreads about 75% faster than BA.1, according to health officials.

"Any time there is a more transmissible virus, it has the chance of becoming the predominant virus across the world," said Hannah Barbian, a genomic epidemiologist at the Regional Innovative Public Health Lab at Rush University Medical Center.

Experts said COVID vaccines have been effective against all variants that have surfaced, when it comes to preventing hospitalizations and death. More studies, however, are needed to see what impact vaccines could have on the XE variant.

So far during the pandemic, new strains and surges have hit Europe and China first, which is why scientists are watching what happens there closely.

"The U.S. hasn’t seen evidence for a new surge yet, so I think this could be the exception. We’re not sure, but I think we always want to know viral dynamics in our area," said Hannah Barbian, a genomic epidemiologist at the Regional Innovative Public Health Lab at Rush University Medical Center.

Incoming White House COVID-19 Response Coordinator Dr. Ashish Jha talks about the new omicron sub-variant BA.2 and whether the U.S. will see the kind of surge that Europe and Asia are experiencing.
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