The Ramblers, who hadn't reached the Final Four since 1963, became the fourth 11-seed to reach the semifinals since 1979 after beating Kansas State Saturday night.
Former President Barack Obama expressed his excitement on Twitter Sunday morning, congratulating the team for their continued victory.
"Incredible to have a Chicago team in the Final Four," Obama, a Chicago native, tweeted. "I'll take that over an intact bracket any day! Congratulations to everybody @LoyolaChicago - let's keep it going!"
After winning their first three games by a combined four points, the Ramblers beat the Wildcats with ease, winning by 16 points and making history in the process.
The Ramblers will either take on Michigan or Florida State in the semifinals, which will take place next Saturday.