The inadvertent release of "petroleum-based material" prompted the closure of Arsenal Road, near Interstate 55 on Friday.
The nearby ExxonMobile refinery says the material was a mixture of gasoline and other chemicals and may have coated homes and vehicles, in addition to the shutdown of Arsenal Road between I-55 and Baseline road.
County spokeswoman Anastasia Tuskey said the release is not considered a health hazard.
"The only reason (the road) was closed is because it got a little slippery," she said.
County highway crews have been laying sand on the road to make it drivable again. The sheriff’s department said it would remain closed for the rest of the business day Friday.
ExxonMobil said it is taking the following steps because of the release:
Sheriff’s police late Friday morning were checking other area roads to see if they were affected, including area between I-55, where the refinery is located, and Route 53.