Nolan Reimold hit a two-run homer off Jason Frasor in the 10th inning, and the Baltimore Orioles beat the White Sox 6-4 Wednesday night to end Chicago's five-game winning streak.
J.J. Hardy went 4-for-5 with a home run for the last-place Orioles, who blew a four-run lead before winning for only the second time in eight games.
After Chris Davis singled off Frasor (2-2) with one out in the 10th, Reimold hit the next pitch over the center-field wall.
Mike Gonzalez (2-2) worked the 10th for the Orioles, who also got a home run from Adam Jones.
The loss ended Chicago's seven-game road winning streak and kept the White Sox four games behind first-place Detroit in the AL Central. The defeat also ruined Chicago's bid to reach .500 for the first time since July 29.
Making his second start for Baltimore since coming over in a July 30 trade with the Texas Rangers, Tommy Hunter took a 4-1 lead into the seventh. He got two outs before No. 9 hitter Brent Morel doubled in a run, putting runners at second and third.
Right-hander Jason Berken came in to face left-handed hitter Juan Pierre, who grounded the first pitch inside the third-base line for a two-run single, tying the score at 4.
Hunter gave up four runs and seven hits. In his two starts with the Orioles, he has not yielded a walk in 10 2-3 innings.
White Sox starter Philip Humber allowed four runs and 11 hits in six innings. He was 0-4 with a 7.97 ERA in his prior four starts.
After previously being outscored 82-35 in the first inning this season, Baltimore took a 1-0 lead before making two outs. Hardy hit his 21st home run, and Nick Markakis and Jones both singled before Humber retired Matt Wieters and Mark Reynolds.
The Orioles reversed another trend in their next crack at Humber. Held hitless in the second inning of its last 11 games, Baltimore used four singles and a sacrifice fly to make it 3-0. Robert Andino singled in a run and scored on a bases-loaded fly ball by Markakis.
The White Sox didn't get a runner in scoring position until Alex Rios led off the fifth with a double. He did not advance.
Jones led off the bottom half with his 21st home run, increasing his team-high RBI total to 71.
Chicago closed to 4-1 in the sixth. Pierre hit a bloop to left that a charging Felix Pie gloved with a dive, but the ball squirted free for a double. Pierre advanced on a fly ball and scored on a groundout by Konerko.