Hector Santiago allowed two in five-plus innings filling in for Jake Peavy on Thursday night, Tyler Flowers hit a three-run homer and the Chicago White Sox beat Texas 3-1, handing the Rangers their first series loss of the season.

Flowers' drive just inside the foul pole in left field was the third straight hit after Texas right-hander Justin Grimm (2-1) retired 10 in a row on the day he was named AL rookie of the month.

Adrian Beltre's homer in the second was the only hit through five innings against Santiago (1-1), who had six strikeouts and two walks in 5 1-3 innings. The left-hander made his first start of the season and fifth of his career after Peavy was scratched because of back spasms.