Jayson Werth and Scott Hairston hit three-run homers to lead the Washington Nationals to an 11-6 win over the Chicago Cubs on Wednesday.

Werth's three-run homer in the third inning off Jake Arrieta gave the Nationals a 6-1 lead and was his eighth since the All-Star break.

Hairston, who was traded by the Cubs on July 8, was pinch-hitting for Tanner Roark and hit his off James Russell (1-4) with two outs in the seventh to give the Nationals a 9-6 lead after they had given up a 6-1 lead.

Anthony Rizzo, hitting second for the first time in his career as part of an altered Cubs lineup, hit his first two homers since Aug. 6 and had three RBIs, but couldn't stop the Cubs from losing their 15th in their past 18 at home.

Ross Ohlendorf was activated off the disabled list before Wednesday's game by Washington and allowed four runs and six hits and 4 1-3 innings.