Carlos Quentin hit a three-run homer, Ross Ohlendorf pitched effectively into the seventh inning and the San Diego Padres ruined Brooks Raley's major league debut Tuesday night with a 7-4 victory over the floundering Chicago Cubs.
Chase Headley and Everth Cabrera each drove in two runs for San Diego, which has won eight of 10 at home.
Chicago lost its seventh consecutive game and has been outscored 38-16 during the slide.
Promoted from Triple-A Iowa, Raley (0-1) lasted four innings while allowing seven runs and eight hits. The left-hander had four strikeouts and three walks as a replacement for injured starter Matt Garza.
Ohlendorf (4-2) gave up one unearned run and three hits in six-plus innings. He was pulled after Bryan LaHair reached on a two-base error by right fielder Chris Denorfia leading off the seventh.
Huston Street, the fifth Padres reliever, pitched a perfect ninth for his 20th save in as many chances.
San Diego held the Cubs to five hits for the second straight night, including a 2-0 victory Monday.
The Padres teed off on Raley, the Cubs' sixth-round draft pick in 2009.
Although there were only two baserunners in the first two innings, the rookie threw 37 pitches. Then in the third, Ohlendorf got things going with a leadoff single.
After a walk to Denorfia and Logan Forsythe's infield single loaded the bases, Headley lined a two-run single to center. After another walk loaded the bases again, Cabrera's two-out single drove in two more runs.
Raley ran into more trouble in the fourth when he allowed a pair of singles with two outs. He then hung an off-speed pitch that Quentin hit for a three-run homer to left.
Quentin is 9 for 18 with four homers and nine RBIs against the Cubs this season.
The Cubs scored in the fifth on consecutive two-out doubles by Luis Valbuena and Darwin Barney.
Chicago rallied in the seventh after LaHair reached on Denorfia's error and scored on Steve Clevenger's single off Brad Boxberger. Barney was hit by a pitch with one out before rookie Josh Vitters hit a two-run double for his first major league hit.
Cubs rookie Brett Jackson, who struck out four times Monday night, whiffed three more times Tuesday. In his first 11 major league at-bats, Jackson has fanned eight times.