Jeff Samardzija struck out Miguel Cabrera with the bases loaded in the eighth inning — but as big as that moment seemed, there was another power threat waiting on deck.

Victor Martinez cleared the bases with a tying double off Samardzija, and the Chicago White Sox went on to lose 5-4 to Detroit on Sunday. James McCann hit a solo home run in the ninth to win it.

Chicago was ahead 4-0 in the eighth, but Samardzija couldn't hold the lead.

"After he got Miggy, and especially the way he did it, he obviously still had something left in the tank to go after Victor," White Sox manager Robin Ventura said. "We were going hitter by hitter that inning, and we felt like Jeff was the best matchup."

Samardzija allowed only two hits over the first seven innings, but McCann started the bottom of the eighth with a single. After a walk by Jose Iglesias and a single by Anthony Gose, the Chicago right-hander hit Ian Kinsler to force home the first Detroit run.

Cabrera struck out, but Martinez found the gap in right-center to clear the bases on Samardzija's 110th and final pitch.

Joakim Soria (3-0) pitched a perfect top of the ninth, and McCann's one-out drive off Zach Putnam (1-3) cleared the fence in left field to end the game.

"An 0-2 pitch, I was just looking for something up," McCann said. "I knew it had a chance."

It was McCann's third homer of the year and his first since May 21, when the Detroit catcher went deep in the 11th inning to beat Houston.

Melky Cabrera homered and had three hits for the White Sox, who scored two runs each in the fourth and sixth. Detroit's David Price allowed four runs and six hits in six innings. He struck out five.

Price allowed only one hit through the first three innings, but Jose Abreu led off with a double in the fourth — then advanced to third when Detroit's Yoenis Cespedes fell over while picking up the ball at the fence in left for an error. Avisail Garcia followed with a sacrifice fly, and Melky Cabrera made it 2-0 with his second homer of the season.

Adam Eaton tripled to start Chicago's sixth-inning rally. He scored on Garcia's single, and Adam LaRoche added a sacrifice fly.