Justin Ruggiano, Mike Olt and Welington Castillo hit two-run homers to power the Chicago Cubs to a 16-9 victory over the Boston Red Sox on Wednesday night, completing a three-game interleague series sweep.
Ruggiano drove in five runs, Darwin Barney had four hits and Nate Schierholtz added a solo homer for Chicago, which won for the sixth time in seven games away from Wrigley Field and posted its first interleague sweep of three or more games since taking three from Cleveland in 2009.
It was the Cubs' first interleague sweep on the road since winning three against the crosstown rival White Sox in 2007.
Mookie Betts hit his first major league homer for the Red Sox, who lost for the ninth time in 13 games.
Red Sox DH David Ortiz became the 36th player in major league history to collect 1,000 extra-base hits with a ground-rule double.
Boston had its streak of holding an opponent to three or fewer runs in 14 straight home games snapped, the longest single-season stretch since the 1917 White Sox did it in 20.
Unlike the first two games of the series when the teams combined for five runs and Boston was held hitless for 7 2-3 innings in the opener, there was plenty of offense to force both starting pitchers out early.
The teams combined for nine runs in the ninth inning — Chicago scored six — in a game that took 4 hours, 19 minutes.
Carlos Villanueva (4-5) allowed two runs in two innings of relief for the win.
Red Sox starter Brandon Workman (1-2) allowed six runs and five hits in four innings. Travis Wood lasted just 3 2-3, giving up three runs and seven hits.
The Cubs jumped ahead 3-0 before making an out in the first. Ruggiano homered off a billboard above the Green Monster seats after Chris Coghlan drew a leadoff walk. Anthony Rizzo walked, stole second and scored on Starlin Castro's single. Workman then struck out Luis Valbuena, bringing a loud mock cheer from the sweltering crowd.
Boston's Jonny Gomes had a sacrifice fly before Chicago built its lead to 6-1 in the fourth. Olt hit his two-run homer into Monster seats and Barney tripled and scored on Coghlan's sacrifice fly.
Ortiz had a sacrifice fly and Gomes an RBI single, slicing it to 6-3, but Castillo homered into the center-field bleachers off reliever Felix Doubront in the fifth.
Betts homered into the Monster seats. Schierholtz homered in the eighth when many of the sellout crowd had already left.