Thomas M. Glaab, 28, Rodney L. Brown, 35, and Miguel Robles-Moya, 35, escaped from Tri-County Detention Center in southern Illinois.
Authorities say they have few clues as they hunt for three federal prisoners who bolted from a detention center near the southern Illinois town of Ullin.
Brown has slipped out of jail before. He and another man climbed over a fence in the recreation area of the Morris County Jail in Texas on Aug. 13, 2006 while he was serving a 60-year prison term.
Twenty-eight-year-old drug defendant Thomas Glaab of Anna has relations in southern Illinois.
Chief Deputy U.S. Marshal Karen Simons said Thursday that authorities don't know if the men stayed together.
Anyone with information about the men should call U.S. Marshals at 618-482-9336.