"If I know, then there might be a blame for it," Tyson told Oprah. "And if there's somebody to blame for it, there will be a problem."
The young girl, whom Tyson referred to as "my angel," died May 26 at a Phoenix hospital, a day after her neck apparently was caught in a treadmill cord.
He says he's slowly healing from the incident.
"My first instinct was a lot of rage, you know, and I was so happy that I had the tools in life, you know, to not go in that direction because I've been that direction. I know where that's gonna lead me. I know I'm not gonna win."
Tyson called his family "my biggest asset." He also says his children are "the only thing that matters to me now."
The former champ has had somewhat of a pop-culture resurgence lately. He was the subject of the recent movie "Tyson," which was based on interviews with the boxer and also made a turn in the blockbuster comedy "The Hangover" earlier this year.