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Talk show host Oprah Winfrey smiles as she talks to reporters before for the Chicago premier of "The Color Purple" Thursday, May 3, 2007. (AP Photo/Charles Rex Arbogast)
Oprah is taking over Sesame Street.
For the first time ever, the talk show queen lends her voice to the award winning show for preschoolers in a chat parody called "The O Show". The episode portrays her as an animated "O" chatting with guests such as "Otto the Orangutan" and "Ophelia the Octopus."
The new season of Sesame Street also features a number of parodies of other TV shows and movies. It will also include appearances by celebrities such as pop singers Katy Perry, Usher and Will.i.am, and actors Colin Farrell, and Jude Law.
The episode will air next Monday, September 27th for the show's 41st season premiere on PBS.
Check out a clip of "The O Show" on Sesame Street below.