Daley appointed Paul Volpe to the post on Wednesday. Volpe has been the city's chief financial officer. Before that, the 45-year-old was the city's budget director.
Volpe replaces Lori Healy who has been Daley's chief of staff since last year.
She's stepping down to head Chicago's bid for the 2016 Summer Games. Starting next month, the 49-year-old will be in charge of community outreach, government relations and Olympic Village development.
The staff changes are among several others announced recently.
Last week, Chicago's budget director Bennett Johnson III resigned.