Alfredo Simon became the NL's first 12-game winner and Billy Hamilton added to his sensational series with a tiebreaking triple Wednesday night, leading the Cincinnati Reds to a 4-1 victory over the trade-depleted Chicago Cubs.

The Reds won their fifth in a row — matching their season high — and moved a season-best seven games over .500. After winning the first four games of the series, they'll try for their first five-game sweep since 1976 on Thursday.

Simon (12-3), left off the All-Star team, became the first Reds pitcher to win a dozen games before the break since Edinson Volquez also went 12-3 in the first half of 2008. The reliever-turner-starter gave up four hits in 6 2-3 innings, including Anthony Rizzo's third homer in four games.

Hamilton tripled home a run and scored during a three-run fifth against Dallas Beeler (0-2), who has lost his first two starts in the majors. Cubs manager Rick Renteria was ejected during the inning for arguing a foul ball call with third base umpire Andy Fletcher.

Hamilton is 7 for 15 with three triples, three walks, two steals and seven RBIs during the series. On Tuesday night, his ninth-inning single completed the Reds' comeback from a five-run deficit to a 6-5 win and a doubleheader sweep. He left the game in the eighth with a tight left hamstring.

Reds second baseman Brandon Phillips also left in the eighth after spraining his left thumb while making a sliding catch. X-rays were negative.

It's been a tough week for the Cubs, who have lost all six games — their deepest slump of the season — since they dealt starters Jeff Samardzija and Jason Hammel to Oakland for a package of prospects.

Beeler and several others will get a chance to move up from the minors and fill their spots. The 25-year-old pitcher gave up four runs, six hits and four walks in five innings.

Simon has been one of the majors' biggest surprises. Moved into the rotation when Mat Latos tore knee cartilage in spring training, the 33-year-old pitcher is having by far the best year of his career, ranking among the league leaders in several categories.

The right-hander walked two, matched his season high with eight strikeouts and threw 119 pitches, retiring 13 in a row during one stretch.

Aroldis Chapman struck out the side in the ninth for his 19th save in 21 chances. The left-hander has fanned at least one batter in each of his last 38 appearances, leaving him one shy of Bruce Sutter's record for a reliever since 1900.

The Cubs called up second baseman Arismendy Alcantara for a couple of days. The 22-year-old infielder was in the starting lineup, batted second and went 0 for 4 with two strikeouts. He'll return to Triple-A Iowa when second baseman Darwin Barney returns from paternity leave.