Wright, 43, filed for divorce Aug. 12 in San Rafael, Calif., citing irreconcilable differences with Penn, 49, her husband of more than a decade. The couple have agreed to share custody of their 16-year-old son Hopper Jack.
The couple also has an 18-year-old daughter, Dylan Francis.
Publicists for Wright and Penn didn't immediately return e-mails seeking comment Wednesday. A message for Wright's lawyer, Bruce Clemens, was also not immediately returned.
The couple, married in April 1996, have filed for separation or divorce twice before, only to dismiss their petitions.
Penn asked for separation as recently as April. But he later withdrew the petition, telling the New York Daily News the filing was "an arrogant mistake."
The couple met on the set of the 1990 Irish mob movie "State of Grace." Penn had previously married and divorced Madonna, and Wright was married once before to former soap star Dane Witherspoon.
They attended the Academy Awards together in February when Penn received an Oscar for his role in "Milk." But he didn't thank Wright in his acceptance speech.
It was Penn's second Oscar. He had won previously for his role in "Mystic River."
Wright is best known for her roles in "The Princess Bride" and "Forrest Gump."
The couple has been ordered to appear in court on Dec. 17 in the divorce case, according to court filings.