Mayor Rahm Emanuel talked up his administration's efforts to spur economic development and job creation across the city during a speech Tuesday to The Executive's Club of Chicago.
Hundreds of jobs will be heading to Chicago in the next three years.
Dow says most of the jobs will be sales professional positions serving the Midwest.
The new downtown facility where the company will base itself will be a regional center for multiple businesses and a conference center, but it is not known where the building is located.
"Dow's commitment to Chicago is a reflection of the great work ethic and business environment in the city," said Emanuel in a statement.
Heinz Haller, Dow Executive Vice President and Chief Commercial Officer, says the decision "is part of a strategic move to support Dow's growth agenda of becoming a more customer-oriented organization and increase sales in our specialty products portfolio."
The Mayor's Office says Dow received no incentives to create the positions in Chicago.
Since Emanuel took office in May, 13 companies have announced new jobs in the city